Repotentiating Beat lactam antibiotics (REBEL)


Resistance to beta-lactam antibiotics is a major problem in health care. Often this problem is caused by bacteria that produce beta-lactamase enzymes, which degrade this group of antibiotics. This can be prevented by administering the antibiotic together with a substance which inhibits the enzyme from the bacterium. In this way existing beta-lactam antibiotics can be made usable again. Mariël Pikkemaat is coordinating a consortium of Canadian, Swedish and Dutch researchers working in a JPI Anti-Microbial Resistance project to find new beta-lactamase inhibitors.